Валидированные методы
Разработка и валидация биоаналитических методик проводится в соответствии с требованиями ФГБУ «НЦЭСМП» Минздрава России, Евразийского экономического союза, FDA и EMA. Под вашу задачу может быть разработана высокочувствительная аналитическая методика, отвечающая требованиям протокола клинического исследования.
Compound (Metabolite, Biomarker) |
Matrix |
Method |
LLOQ |
Status* |
|
Abacavir |
Plasma |
LC-MS/MS |
50 ng/mL |
Active |
|
Abacavir/ Lamivudine |
Plasma |
LC-MS/MS |
50 ng/mL 50 ng/mL |
Active |
|
Abiraterone |
Plasma |
LC-MS/MS |
0.2 ng/mL |
Active |
|
Acetaldehyde |
Plasma |
LC-MS/MS |
10 ng/mL |
Active |
|
Acetaminophen / Chlorpheniramine |
Plasma |
LC-MS/MS |
10 ng/mL 0.1 ng/mL |
Active |
|
Acetaminophen / Caffeine |
Plasma |
LC-MS/MS |
10 ng/mL 100 ng/mL |
Active |
|
Acetylsalicylic acid / Salicylic acid |
Plasma |
LC-MS/MS |
4 ng/mL 15 ng/mL |
Active |
|
Acotiamide |
Plasma |
LC-MS/MS |
0.5 ng/ml |
Active |
|
Ademethionine |
Plasma |
LC-MS/MS |
10 ng/mL |
Active |
|
Ambroxol |
Plasma |
LC-MS/MS |
1 ng/mL |
Active |
|
Ambroxol / Cetirizine |
Plasma |
LC-MS/MS |
1 ng/mL 4 ng/mL |
Active |
|
p-Aminosalicylic acid |
Plasma |
LC-MS/MS |
50 ng/mL |
Active |
|
Amlodipine |
Plasma |
LC-MS/MS |
0.2 ng/mL |
Active |
|
Amlodipine / Metoprolol |
Plasma |
LC-MS/MS |
0.2 ng/mL 0.1 ng/mL |
Active |
|
Amlodipine / Telmisartan |
Plasma |
LC-MS/MS |
0.2 ng/mL 2.5 ng/mL |
Active |
|
Amoxicilline / Clavulanic acid |
Plasma |
LC-MS/MS |
100 ng/mL 50 ng/mL |
Active |
|
Anagrelide |
Plasma |
LC-MS/MS |
50 pg/mL |
Active |
|
Anandamide |
Plasma |
LC-MS/MS |
0.1 ng/mL |
Active |
|
2-Arachidonoyl glycerol |
Plasma |
LC-MS/MS |
0.5 ng/mL |
Active |
|
Arginine |
Plasma |
LC-MS/MS |
4 µg/mL |
Active |
|
Atazanavir |
Plasma |
LC-MS/MS |
5 ng/mL |
Active |
|
Atorvastatin |
Plasma |
LC-MS/MS |
0.2 ng/mL |
Active |
|
Atorvastatin / Valsartan |
Plasma |
LC-MS/MS |
0.2 ng/mL 10 ng/ml |
Active |
|
Azacitidine |
Plasma |
LC-MS/MS |
3 ng/ml |
Active |
|
Bosentan |
Plasma |
LC-MS/MS |
5 ng/mL |
Active |
|
Bicalutamide |
Plasma |
LC-MS/MS |
10 ng/mL |
Active |
|
Bisoprolol |
Plasma |
LC-MS/MS |
0.5 ng/mL |
Active |
|
Buspirone / 6-Hydroxy buspirone / 2-(1-Piperazinyl)pyrimidine (1-PP) |
Plasma |
LC-MS/MS |
20/50pg/mL 0.5 ng/mL |
Active |
|
Capecitabine / 5-Fluorouracil |
Plasma |
LC-MS/MS |
20 ng/mL 20 ng/mL |
Active |
|
Celecoxib |
Plasma |
LC-MS/MS |
10 ng/mL |
Active |
|
Cetirizine (Levocetirizine) |
Plasma |
LC-MS/MS |
1 ng/mL |
Active |
|
Chlorpromazine |
Plasma |
LC-MS/MS |
1 ng/mL |
Active |
|
Choline |
Plasma |
LC-MS/MS |
50 ng/mL |
Active |
|
Cinacalcet |
Plasma |
LC-MS/MS |
0.1 ng/mL 0.05 ng/mL |
Active |
|
Cisplatine |
Plasma |
LC-MS/MS |
1 ng/mL |
Active |
|
Citalopram |
Plasma |
LC-MS/MS |
0.3 ng/mL |
Active |
|
Clopidogrel / Carboxylic acid Clopidogrel |
Plasma |
LC-MS/MS |
10 pg/ml 100 ng/mL |
Active |
|
Coenzyme Q10 / reduced Coenzyme Q10 (ubiquinol)/ Coenzyme Q9 |
Plasma Tissue |
LC-MS/MS |
1 µg/mL |
Active |
|
Corticosterone |
Urine |
LC-MS/MS |
5 ng/mL |
Active |
|
Cortineff |
Urine |
LC-MS/MS |
1 ng/mL |
Inactive |
|
Cortisol (6ß-Hydroxycortisol) |
Urine |
LC-MS/MS |
5 ng/mL |
Active |
|
Cortisone |
Urine |
LC-MS/MS |
5 ng/mL |
Active |
|
Creamide |
Plasma |
LC-MS/MS |
0.1 µg/mL |
Active |
|
Cycloserine |
Plasma |
LC-MS/MS |
0.3 µg/mL |
Active |
|
Dabigatran free/total |
Plasma |
LC-MS/MS |
0.5 ng/mL |
Active |
|
Dapoxetine |
Plasma |
LC-MS/MS |
1 ng/mL |
Active |
|
Darunavir |
Plasma |
LC-MS/MS |
50 ng/mL |
Active |
|
Dasatinib |
Plasma |
LC-MS/MS |
1 ng/mL |
Active |
|
Desloratadin |
Plasma |
LC-MS/MS |
50 pg/ml |
Active |
|
Dexamethasone |
Urine |
LC-MS/MS |
1 ng/mL |
Active |
|
Dexketoprofen |
Plasma |
LC-MS/MS |
50 ng/mL |
Active |
|
Diclofenac / Tolperisone |
Plasma |
LC-MS/MS |
50 ng/mL 0.5 ng/mL |
Active |
|
Docetaxel |
Plasma |
LC-MS/MS |
2 ng/mL |
Active |
|
Dopamine |
Plasma Urine |
HPLC/ED |
0.35 ng/mL |
Active |
|
Doxazosin |
Plasma |
LC-MS/MS |
0.3 ng/mL |
Active |
|
Doxepin / N-Desmethyldoxepin |
Plasma |
LC-MS/MS |
100 pg/ml 100 pg/ml |
Active |
|
Doxorubicin |
Plasma Tissue |
LC-MS/MS |
0.5 ng/mL |
Active |
|
Doxylamine |
Plasma |
LC-MS/MS |
0.2 ng/mL |
Active |
|
Drospirenone |
Plasma |
LC-MS/MS |
0.2 ng/mL |
Active |
|
Dutasteride / Tamsulosin |
Plasma |
LC-MS/MS |
0.1/ 0.2 ng/mL |
Active |
|
Ebastine Carebastin |
Plasma |
LC-MS/MS |
Development |
||
Efavirenz |
Plasma |
LC-MS/MS |
100 ng/mL |
Active |
|
Emtricitabine |
Plasma |
LC-MS/MS |
20 ng/mL |
Active |
|
Emtricitabine / Tenofovir |
Plasma |
LC-MS/MS |
10 ng/mL 4 ng/mL |
Active |
|
Enalapril |
Plasma |
LC-MS/MS |
0.5 ng/mL |
Active |
|
Entecavir |
Plasma |
LC-MS/MS |
0.1 ng/mL |
Active |
|
Epinephrine |
Plasma Urine |
HPLC/ED |
0.2 ng/mL |
Active |
|
Eplerenone |
Plasma |
LC-MS/MS |
25 ng/mL |
Active |
|
Estradiol (Unconjugated) / Estrone (Unconjugated) |
Plasma |
LC-MS/MS |
3 pg/ml / 8 pg/ml |
Active |
|
Estrone (Totall) |
Plasma |
LC-MS/MS |
0.1 ng/mL |
Pre-Active |
|
Eremomycin |
Plasma |
LC-MS/MS |
50 ng/mL |
Active |
|
Esomeprazole |
Plasma |
LC-MS/MS |
1 ng/mL |
Active |
|
Ethinyl Estradiol |
Plasma |
LC-MS/MS |
3 pg/ml |
Active |
|
Ethyl lysine |
Plasma |
LC-MS/MS |
20 ng/mL |
Active |
|
Etoricoxib |
Plasma |
LC-MS/MS |
10 ng/mL |
Active |
|
Ezetimibe / Ezetimibe Glucuronide |
Plasma |
LC-MS/MS |
0.1 ng/mL 1 ng/mL |
Active |
|
Febuxostat |
Plasma |
LC-MS/MS |
50 ng/mL |
Active |
|
Fexofenadine |
Plasma |
LC-MS/MS |
1 ng/mL |
Active |
|
Finasteride |
Plasma |
LC-MS/MS |
0.5 ng/mL |
Active |
|
Fingolimod ( FTY720 )/ Fingolimod phosphate ( FTY720-P) |
Blood |
LC-MS/MS |
50 pg/mL 70 pg/mL |
Active |
|
Fingolimod ( FTY720 ) |
Blood |
LC-MS/MS |
20 pg/mL |
Active |
|
Fosfomycin |
Plasma |
LC-MS/MS |
1 mkg/ml |
Active |
|
Furazidin |
Plasma |
LC-MS/MS |
- |
Development |
|
Gliclazide |
Plasma |
LC-MS/MS |
20 ng/mL |
Active |
|
Homovanillic acid |
Urine |
HPLC/ED |
10 ng/mL |
Active |
|
Ibandronic Acid |
Plasma |
LC-MS/MS |
0.8 ng/mL |
Active |
|
Ibuprofen |
Plasma |
LC-MS/MS |
200 ng/mL |
Active |
|
Imatinib |
Plasma |
LC-MS/MS |
5 ng/mL |
Active |
|
Inosine / Methionine / Nicotinamide |
Plasma |
LC-MS/MS |
1/3 mkg/ml 200 ng/ml |
Active |
|
Irbesartan |
Plasma |
LC-MS/MS |
5 ng/mL |
Active |
|
Itopride |
Plasma |
LC-MS/MS |
5 ng/mL |
Active |
|
Ketorolac |
Plasma |
LC-MS/MS |
10 ng/mL |
Active |
|
Kynurenine |
Plasma |
HPLC/UV |
10 ng/mL |
Inactive |
|
Kynurenic acid |
Plasma |
HPLC/UV |
20 ng/mL |
Inactive |
|
Lamotrigine |
Plasma |
LC-MS/MS |
10 ng/mL |
Active |
|
Lenalidomide |
Plasma |
LC-MS/MS |
1 ng/mL |
Active |
|
Lercanidipine |
Plasma |
LC-MS/MS |
50 pg/ml |
Active |
|
Levetiracetam |
Plasma |
LC-MS/MS |
200 ng/mL |
Active |
|
Levofloxacin |
Plasma |
LC-MS/MS |
250 ng/mL |
Active |
|
Levonorgestrel |
Plasma |
LC-MS/MS |
0.1 ng/mL |
Active |
|
Lidocaine |
Plasma |
LC-MS/MS |
1 ng/mL |
Active |
|
Linezolid |
Plasma |
LC-MS/MS |
100 ng/mL |
Active |
|
Lipoic acid |
Plasma |
LC-MS/MS |
5 ng/mL |
Active |
|
Lisinopril |
Plasma |
LC-MS/MS |
5 ng/mL |
Active |
|
Losartan |
Plasma |
LC-MS/MS |
5 ng/mL |
Active |
|
Losartan / Hydrochlorothiazide |
Plasma |
LC-MS/MS |
1.5 ng/mL 1 ng/mL |
Active |
|
Marcaine |
Plasma Tissue |
LC-MS/MS HPLC/UV |
1 ng/mL |
Active |
|
Mebeverin Acid/ o-desmethyl mebeverine acid |
Plasma |
LC-MS/MS |
1 ng/mL 5 ng/mL |
Active |
|
Melatonin |
Plasma |
LC-MS/MS |
10 pg/ml |
Active |
|
Meloxicam |
Plasma |
LC-MS/MS |
10 ng/mL |
Active |
|
Melphalan |
Plasma Tissue |
LC-MS/MS |
0.3 ng/mL |
Active |
|
Memantine |
Plasma |
LC-MS/MS |
0.3 ng/mL |
Active |
|
Metanephrine |
Urine |
HPLC/ED |
10 ng/mL |
Active |
|
Metformin / Sitagliptin |
Plasma |
LC-MS/MS |
10 ng/mL 1 ng/mL |
Active |
|
Metoprolol |
Plasma |
LC-MS/MS |
0.1 ng/mL |
Active |
|
Mexidol (Emoxypine) |
Plasma |
LC-MS/MS |
0.5 ng/mL |
Active |
|
Mildronate |
Plasma |
LC-MS/MS |
50 ng/mL |
Active |
|
4-Methylaminoantipyrine (Metamizole metabolite) |
Plasma |
LC-MS/MS |
100 ng/mL |
Active |
|
Mitomicyn C |
Plasma Tissue |
LC-MS/MS |
0.6 ng/mL |
Active |
|
Mitotane |
Plasma |
HPLC-UV |
0.75 mkg/mL |
Active |
|
Mitoxantrone |
Plasma Tissue |
LC-MS/MS |
5 ng/mL |
Inactive |
|
Monomethyl fumarate |
Plasma |
LC-MS/MS |
10 ng/mL |
Active |
|
Montelukast/ Cetirizine |
Plasma |
LC-MS/MS |
10 ng/mL 1 ng/mL |
Active |
|
Moxifloxacin |
Plasma |
LC-MS/MS |
2 ng/mL |
Active |
|
Moxonidine |
Plasma |
LC-MS/MS |
50 pg/mL |
Active |
|
Naftidrofuryl |
Plasma |
LC-MS/MS |
10 ng/mL |
Active |
|
Naloxone |
Plasma |
LC-MS/MS |
80 pg/mL |
Active |
|
Naltrexone |
Plasma |
LC-MS/MS |
150 pg/mL |
Active |
|
Nevirapine |
Plasma |
LC-MS/MS |
80 ng/mL |
Active |
|
Nifedipine/ Lidocaine |
Plasma |
LC-MS/MS |
0.5 ng/mL 1 ng/mL |
Active |
|
Nilotinib |
Plasma |
LC-MS/MS |
2 ng/mL |
Active |
|
Nimesulide |
Plasma |
LC-MS/MS |
20 ng/mL |
Active |
|
Nitisinone |
Plasma |
LC-MS/MS |
5 ng/mL |
Active |
|
Norepinephrine |
Plasma Urine |
HPLC/ED |
0.2 ng/mL |
Active |
|
Normetanephrine |
Urine |
HPLC/ED |
5 ng/mL |
Active |
|
Oxybutynin |
Plasma Tissue |
LC-MS/MS |
0.5 ng/mL |
Active |
|
Oseltamivir carboxylate |
Plasma |
LC-MS/MS |
2 ng/mL |
Active |
|
PAS (4-Aminosalicylic acid) |
Plasma |
LC-MS/MS |
50 ng/mL |
Active |
|
Pazopanib |
Plasma |
LC-MS/MS |
300 ng/mL |
Active |
|
Penciclovir |
Plasma |
LC-MS/MS |
50 ng/mL |
Active |
|
Perindopril / Perindoprilat |
Plasma |
LC-MS/MS |
0.4 ng/mL 0.4 ng/mL |
Active |
|
Perindoprilat / Indapamide |
Plasma |
LC-MS/MS |
0.4 ng/mL 0.3 ng/mL |
Active |
|
Phenibut |
Plasma |
LC-MS/MS |
10 ng/mL |
Active |
|
Phenylephrine |
Plasma |
LC-MS/MS |
30 pg/ml |
Active |
|
Pirfenidone |
Plasma |
LC-MS/MS |
5 ng/mL |
Active |
|
Pregabalin |
Plasma |
LC-MS/MS |
50 ng/mL |
Active |
|
Rabeprazole |
Plasma |
LC-MS/MS |
2 ng/mL |
Active |
|
Ranolazine |
Plasma |
LC-MS/MS |
5 ng/mL |
Active |
|
Ramipril / Ramiprilat |
Plasma |
LC-MS/MS |
0.2 ng/mL 0.5 ng/mL |
Active |
|
Ritonavir |
Plasma |
LC-MS/MS |
5 ng/mL |
Active |
|
Rivaroxaban |
Plasma |
LC-MS/MS |
0.5 ng/mL |
Active |
|
Rhein (Diacerein) |
Plasma |
HPLC/UV |
100 ng/mL |
Active |
|
Ropinipole |
Plasma |
LC-MS/MS |
10 pg/mL |
Active |
|
Rosuvastatin |
Plasma |
LC-MS/MS |
0.2 ng/mL |
Active |
|
Salbutamol |
Plasma |
LC-MS/MS |
0.2 ng/mL |
Active |
|
Serotonin |
Plasma |
HPLC/UV |
10 ng/mL |
Active |
|
Sildenafil |
Plasma |
LC- MS/MS |
5 ng/mL |
Active |
|
Sildenafil |
Plasma |
LC-MS/MS |
1 ng/mL |
Active |
|
Sitagliptin |
Plasma |
LC-MS/MS |
1 ng/mL |
Active |
|
Solifenacin |
Plasma |
LC-MS/MS |
0.5 ng/mL |
Active |
|
Spironolactone / Canrenone |
Plasma |
LC-MS/MS |
2 ng/mL 2 ng/mL |
Active |
|
Stavudine |
Plasma |
LC-MS/MS |
30 ng/mL |
Active |
|
Succinic acid |
Plasma |
LC-MS/MS |
0.1 µg/mL |
Active |
|
Sunitinib |
Plasma |
LC-MS/MS |
- |
Development |
|
Tadalafil |
Plasma |
LC-MS/MS |
5 ng/ml |
Active |
|
Tacrolimus |
Blood |
LC-MS/MS |
0.5 ng/mL 0.1 ng/mL |
Active Active |
|
Tamsulosin |
Plasma |
LC-MS/MS |
0.1 ng/mL |
Active |
|
Telmisartan |
Plasma |
LC-MS/MS |
3 ng/mL |
Active |
|
Telmisartan/ Hydrochlorothiazide |
Plasma |
LC-MS/MS |
3 ng/mL 1 ng/mL |
Active |
|
Tenofovir |
Plasma |
LC-MS/MS |
4 ng/mL |
Active |
|
Terbinafine |
Plasma |
LC-MS/MS |
1 ng/mL |
Active |
|
Terizidone |
Plasma |
LC-MS/MS |
0.3 µg/mL |
Active |
|
Thyroxine (T4) |
Serum |
LC-MS/MS |
30 ng/mL |
Active |
|
Ticagrelor / AR-C124910XX |
Plasma |
LC-MS/MS |
5 ng/mL/ 2.5 ng/mL |
Active |
|
Tilorone |
Plasma |
LC-MS/MS |
0.5 ng/mL |
Active |
|
Tolperisone |
Plasma |
LC-MS/MS |
0.5 ng/mL |
Active |
|
Troventol |
Plasma |
LC-MS/MS |
35 pg/mL |
Active |
|
Troxerutin |
Plasma |
LC-MS/MS |
20 pg/ml |
Active |
|
Tryptophan |
Plasma |
HPLC/UV |
10 ng/mL |
Active |
|
Quetiapine |
Plasma |
LC-MS/MS |
1 ng/mL |
Active |
|
Ursodeoxycholic acid |
Plasma |
LC-MS/MS |
50 ng/mL |
Active |
|
Valsartan |
Plasma |
LC-MS/MS |
10 ng/mL |
Active |
|
Vanillyl mandelic acid |
Urine |
HPLC/UV |
10 ng/mL |
Active |
|
Vildagliptin / Metformin |
Plasma |
LC-MS/MS |
2 ng/mL 5 ng/mL |
Active |
|
Vinblastine |
Plasma Tissue |
LC-MS/MS HPLC/UV |
1 ng/mL |
Active |
|
Voriconazole |
Plasma |
LC-MS/MS |
20 ng/mL |
Active |
|
Warfarin |
Plasma |
LC-MS/MS |
5 ng/mL |
Active |
|
Zidovudine |
Plasma |
LC-MS/MS |
40 ng/mL |
Active |
|
Zidovudine / Lamivudine |
Plasma |
LC-MS/MS |
30 ng/mL 25 ng/mL |
Active |
Контакты
Наш адрес:
194156, Санкт-Петербург,
пр. Энгельса, д. 34, литера В, оф. 202